codonw 1.4 Search Results


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Immune receptors SIGLEC-5 and <t>SIGLEC-14,</t> and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).
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Immune receptors SIGLEC-5 and <t>SIGLEC-14,</t> and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).
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Immune receptors SIGLEC-5 and <t>SIGLEC-14,</t> and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).
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Immune receptors SIGLEC-5 and <t>SIGLEC-14,</t> and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).
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Immune receptors SIGLEC-5 and <t>SIGLEC-14,</t> and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).
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Immune receptors SIGLEC-5 and <t>SIGLEC-14,</t> and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).
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Image Search Results


Immune receptors SIGLEC-5 and SIGLEC-14, and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).

Journal: International Journal of Molecular Sciences

Article Title: SIGLEC-5/14 Inhibits CD11b/CD18 Integrin Activation and Neutrophil-Mediated Tumor Cell Cytotoxicity

doi: 10.3390/ijms242417141

Figure Lengend Snippet: Immune receptors SIGLEC-5 and SIGLEC-14, and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).

Article Snippet: The plasmid vectors pRRL PPT SFFV prester SIN (pSIN) contained SIGLEC-5-HA IRES GFP or SIGLEC-14-V5 - IVS-IRES Cherry (Thermo Fisher Scientific, both sequences were codon optimized for expression in human cells) (IVS: intervening sequence from pIRESpuro2, used for enhanced stability of the mRNA), first cloned into pENTR1A, and then recombined using LR Clonase II (Thermo Fischer Scientific, Waltham, MA, USA) with pRRL PPT SFFV prester SIN (pSin) in which a Gateway Cassette was cloned previously.

Techniques: Expressing, Derivative Assay